{"id":40105,"date":"2025-10-31T21:06:17","date_gmt":"2025-10-31T16:06:17","guid":{"rendered":"https:\/\/menamedicalresearch.com\/news\/?p=40105"},"modified":"2025-10-31T21:21:34","modified_gmt":"2025-10-31T16:21:34","slug":"post-cytotoxic-myeloid-neoplasms-a-mena-region-study-of-clinicopathologic-genetic-profile-latency-determinants-and-prognostic-predictors","status":"publish","type":"post","link":"https:\/\/menamedicalresearch.com\/news\/cancers\/post-cytotoxic-myeloid-neoplasms-a-mena-region-study-of-clinicopathologic-genetic-profile-latency-determinants-and-prognostic-predictors\/","title":{"rendered":"Post-cytotoxic myeloid neoplasms: a MENA region study of clinicopathologic, genetic profile, latency determinants and prognostic predictors"},"content":{"rendered":"<p>Post-cytotoxic myeloid neoplasms (<strong>MN-PCT<\/strong>), also known as <strong>therapy-related myeloid neoplasms<\/strong> (<strong>t-MN<\/strong>), represent a heterogeneous group of hematologic malignancies that develop after a patient receives cytotoxic chemotherapy or radiotherapy for an unrelated condition.<\/p>\n<p>These disorders, which include therapy-related myelodysplastic syndrome (t-MDS), acute myeloid leukemia (t-AML), and myelodysplastic\/myeloproliferative neoplasms (t-MDS\/MPN) are <strong>notorious for their aggressive nature, universally poor survival, and a lack of consensus on reliable prognostic indicators.<\/strong> This complexity stems from a combination of the cytotoxic treatment effects, genetic instability, and patient-specific variables.<\/p>\n<p>To address the limited understanding of this entity, a <strong>10-year retrospective, <\/strong>single-center study was conducted at the<strong> National Center for Cancer Care and Research (NCCCR) in Qatar<\/strong>. Analyzing a cohort of 42 MN-PCT patients, this research offers the <strong>first comprehensive dataset on t-MN from the Middle East and North Africa (MENA) <\/strong>region.<\/p>\n<p>The analysis revealed several critical findings. The <strong>most common genetic mutation was found in the TP53 gene<\/strong>,<strong> present in 28.6%<\/strong> of tested cases. Notably, the study found a high prevalence of autoimmune diseases (30.9%) as the original primary condition, a percentage higher than previously documented. A shorter latency period\u2014the time from prior therapy to MN-PCT diagnosis\u2014was significantly associated with previous exposure to alkylating agents and TP53 positivity.<strong> Patients aged 50 or younger demonstrated a longer median survival.<\/strong><\/p>\n<p>Researchers identified multiple factors affecting disease progression and patient outcome. <strong>\u00a0Dyserythropoiesis, Myeloperoxidase downregulation, mutated TP53, and failure to achieve clinical remission were identified as poor prognostic markers.\u00a0<\/strong>A <strong>latency period of \u2265 5 years and TP53 positivity were identified as statistically significant independent factors associated with reduced overall survival<\/strong>. P53 mutation was a common parameter that adversely impacted both MN-PCT survival and overall survival.<\/p>\n<p>This study significantly advances the understanding of MN-PCT in an underrepresented population. The findings underscore the importance of recognizing MN-PCT as a distinct clinical and pathological entity in future classification systems, emphasizing that adverse prognostic factors extend beyond mere genetic influences.<\/p>\n<p><strong>Reference Source<br \/>\n<\/strong>Soliman, D.S., Fareed, S., Chandra, P. et al. (2025). Post-cytotoxic myeloid neoplasms: a comprehensive analysis of clinicopathologic, genetic profile, latency determinants, and potential prognostic predictors- a single centre study. <em>Annals of Hematology<\/em>. DOI: https:\/\/doi.org\/10.1007\/s00277-025-06651-0<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Post-cytotoxic myeloid neoplasms (MN-PCT), also known as therapy-related myeloid neoplasms (t-MN), represent a heterogeneous group of hematologic malignancies that develop after a patient receives cytotoxic chemotherapy or radiotherapy for an unrelated condition. These disorders, which include therapy-related myelodysplastic syndrome (t-MDS), acute myeloid leukemia (t-AML), and myelodysplastic\/myeloproliferative neoplasms (t-MDS\/MPN) are notorious for their aggressive nature, universally &hellip;<\/p>\n","protected":false},"author":1,"featured_media":40107,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-40105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancers"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/comments?post=40105"}],"version-history":[{"count":3,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40105\/revisions"}],"predecessor-version":[{"id":40110,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40105\/revisions\/40110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/media\/40107"}],"wp:attachment":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/media?parent=40105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/categories?post=40105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/tags?post=40105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}