{"id":40317,"date":"2026-02-04T20:59:38","date_gmt":"2026-02-04T15:59:38","guid":{"rendered":"https:\/\/menamedicalresearch.com\/news\/?p=40317"},"modified":"2026-02-04T20:59:38","modified_gmt":"2026-02-04T15:59:38","slug":"%f0%9d%97%94%f0%9d%97%bb%f0%9d%98%81%f0%9d%97%b6-%f0%9d%97%b6%f0%9d%97%bb%f0%9d%97%b3%f0%9d%97%b9%f0%9d%97%ae%f0%9d%97%ba%f0%9d%97%ba%f0%9d%97%ae%f0%9d%98%81%f0%9d%97%bc%f0%9d%97%bf%f0%9d%98%86","status":"publish","type":"post","link":"https:\/\/menamedicalresearch.com\/news\/non-communicable-diseases\/%f0%9d%97%94%f0%9d%97%bb%f0%9d%98%81%f0%9d%97%b6-%f0%9d%97%b6%f0%9d%97%bb%f0%9d%97%b3%f0%9d%97%b9%f0%9d%97%ae%f0%9d%97%ba%f0%9d%97%ba%f0%9d%97%ae%f0%9d%98%81%f0%9d%97%bc%f0%9d%97%bf%f0%9d%98%86\/","title":{"rendered":"\ud835\uddd4\ud835\uddfb\ud835\ude01\ud835\uddf6-\ud835\uddf6\ud835\uddfb\ud835\uddf3\ud835\uddf9\ud835\uddee\ud835\uddfa\ud835\uddfa\ud835\uddee\ud835\ude01\ud835\uddfc\ud835\uddff\ud835\ude06 \ud835\uddee\ud835\uddfb\ud835\uddf1 \ud835\uddd4\ud835\uddfb\ud835\ude01\ud835\uddf6-\ud835\uddee\ud835\uddff\ud835\ude01\ud835\uddf5\ud835\uddff\ud835\uddf6\ud835\ude01\ud835\uddf6\ud835\uddf0 \ud835\uddfd\ud835\uddfc\ud835\ude01\ud835\uddf2\ud835\uddfb\ud835\ude01\ud835\uddf6\ud835\uddee\ud835\uddf9 \ud835\uddfc\ud835\uddf3 \ud835\uddeb\ud835\uddf6\ud835\uddfa\ud835\uddf2\ud835\uddfb\ud835\uddf6\ud835\uddee \ud835\uddf0\ud835\uddee\ud835\uddf3\ud835\uddf3\ud835\uddff\ud835\uddee \ud835\uddf2\ud835\ude05\ud835\ude01\ud835\uddff\ud835\uddee\ud835\uddf0\ud835\ude01"},"content":{"rendered":"<p>A recent study published in <em>Scientific Reports<\/em> highlights the potential the <strong>promising anti-inflammatory and anti-arthritic potential of the seeds of Ximenia caffra<\/strong> <strong><em>(X. caffra)<\/em><\/strong> <strong>as a natural approach to managing Rheumatoid Arthritis (RA).<\/strong><\/p>\n<p>Researchers from Al-Azhar University, Cairo University, Zigazig University, and Sinai University <strong>analyzed the extract\u2019s bioactive profile using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS), identifying key compounds believed to drive the extract\u2019s medicinal properties.<\/strong> These include phenolic acids like citric acid and gallic acid, flavonoids such as catechin, epicatechin, rutin, hyperoside, and isoquercitrin, and procyanidins like Procyanidin B1 and B2.<\/p>\n<p><strong>In laboratory tests, <em>X. caffra<\/em> seed extract demonstrated significant anti-inflammatory activity by inhibiting the lipoxygenase (LOX) enzyme<\/strong> with an IC50 of 26.01 \u00b1 0.85 \u03bcg\/mL. the extract showed a dose-dependent ability to block inflammatory pathways, a result attributed to its high phenolic and flavonoid content.<\/p>\n<p><strong>In Vivo Success in Arthritis Models<\/strong><\/p>\n<p>In animal experiments using a rat model of arthritis, rats were treated with varying doses of <em>X. caffra<\/em> extract (26, 50, and 100 mg\/kg) or the standard drug methotrexate (MTX). <strong>Treatment resulted in reduced joint swelling, improved arthritis scores, and restoration of normal cartilage and muscle tissue. <\/strong>Researchers found that a 26 mg\/kg dose was optimal for reducing arthritis symptoms and restoring the structure of joints and muscles. This dose was effective enough to <strong>restore near-normal joint measurements by the end of the 15-day experiment, performing comparably to the standard drug MTX<\/strong>. Furthermore, treated rats showed improved body weight, indicating a recovery in general health and feeding behavior.<\/p>\n<ul>\n<li><strong>Cartilage Preservation:<\/strong> While untreated arthritic rats showed shrunken, degenerated chondrocytes and synovial tissue damage, those treated with 26 mg\/kg of the extract exhibited regularly preserved chondrocytes and restored joint architecture.<\/li>\n<li><strong>Osteoclast Regulation:<\/strong> The extract helped normalize the size of osteoclasts and significantly reduced the high rates of cell death (apoptosis) caused by the induced arthritis.<\/li>\n<li><strong>Muscle Protection:<\/strong> The treatment also reversed muscle damage, such as myofiber degradation and inflammatory infiltration, restoring normal movement in the animals.<\/li>\n<\/ul>\n<p>The study also found that the<strong> extract modulates the immune system, reducing pro-inflammatory cytokines including IL-1\u03b2, IL-6, IL-17, and IFN-\u03b3, while increasing the anti-inflammatory cytokine IL-4<\/strong>. Additionally, it normalized the activity of osteoclasts. This shift is essential for stopping the progressive tissue destruction seen in rheumatoid arthritis.<\/p>\n<p><strong>Conclusion<\/strong><\/p>\n<p>These findings suggest that <em>X. caffra<\/em> seed extract is a potent natural agent capable of modulating immune responses and preserving joint integrity.\u00a0 Its high biocompatibility and low toxicity make it a promising candidate for long-term, safe therapy. Although further laboratory and clinical validation is still needed, this research points toward a promising, plant-based path for managing rheumatoid arthritis naturally and safely.<\/p>\n<p><em>Article edited and summarized by Dr. Parvin Dr. Parvin Aktar Barbhuiya<\/em><\/p>\n<p>Reference Source: Yosri, M., Mekky, A. E., Elaasser, M. M., Abdel-Aziz, M. M., Youssef, F. S., Kamel, H. A., Al-Habibi, M. M., Helal, E. E., &amp; Amin, B. H. (2026). <em>In vitro anti-inflammatory potential and in vivo anti-arthritis activities of Ximenia caffra extract on antigen-induced arthritis in rats.<\/em> Scientific Reports, 16:797. <a href=\"https:\/\/doi.org\/10.1038\/s41598-025-32300-7\">https:\/\/doi.org\/10.1038\/s41598-025-32300-7<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study published in Scientific Reports highlights the potential the promising anti-inflammatory and anti-arthritic potential of the seeds of Ximenia caffra (X. caffra) as a natural approach to managing Rheumatoid Arthritis (RA). Researchers from Al-Azhar University, Cairo University, Zigazig University, and Sinai University analyzed the extract\u2019s bioactive profile using Liquid Chromatography High Resolution Mass &hellip;<\/p>\n","protected":false},"author":1,"featured_media":40318,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[77],"tags":[],"class_list":["post-40317","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-communicable-diseases"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/comments?post=40317"}],"version-history":[{"count":1,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40317\/revisions"}],"predecessor-version":[{"id":40319,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/posts\/40317\/revisions\/40319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/media\/40318"}],"wp:attachment":[{"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/media?parent=40317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/categories?post=40317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/menamedicalresearch.com\/news\/wp-json\/wp\/v2\/tags?post=40317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}