Cancers
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Breast Cancer in the MENA Region – Somatic Mutation Profiling and Therapeutic Landscape
Breast cancer in the MENA region often presents at a younger age and in more advanced stages. While this suggests a unique biological and genetic profile in this region, the available genomic databases lack adequate data from MENA populations to understand the disease drivers and therapeutic opportunities specific to this demographic. To address this gap, researchers at Hamad Bin Khalifa…
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Cancer Drug Testing could be transformed by this new paper based platform: Spheromatrix
Researchers at New York University Abu Dhabi (NYUAD) have developedย Spheromatrix, a simple and low-cost technology that enables tumor models to be grown, frozen, and stored for future use in cancer drug testing. The study on development and validation of this technology was recently published in Nature Microsystems & Nanoengineering. Three-dimensional (3D) in vitro tumor models are increasingly recognized as essential…
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The Obesity and Cancer Link – Unraveling molecular interconnections and identifying potential therapeutic targets of significance
The link between Obesity and Cancer has emerged as a significant risk factor for a range of malignancies, including melanoma, endometrial, prostate, pancreatic, esophageal adenocarcinoma, colorectal carcinoma, renal adenocarcinoma, and pre-and post- menopausal breast cancer. A narrative review published by researchers from Qatar, Saudi Arabia, UAE, and India offers a comprehensive examination of the molecular interconnections between obesity and cancer…
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Colorectal Cancer in GCC Gulf Countries – Diagnosis and Management: Expert Recommendations
Colorectal Cancer in GCC (Gulf Cooperation Council) countries has incidence rates from 9.9 to 15.9 per 100,000 people. Experts are concerned about a rising trend, especially in individuals less than 50 years old, linked to rapid urbanization, poor diet, low physical activity, and increased hereditary risk due to a high rate of consanguineous marriages. Survival rates in the Gulf are…
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Advancing CAR T-Cell Therapy in Solid Tumours
Chimeric Antigen Receptor (CAR) T-cell therapy has achieved transformative success in treating blood cancers, with certain B-cell malignancies showing complete remission rates exceeding 80%. However, applying this potent immunotherapy to solid tumors remains a formidable challenge. The primary hurdles stem from the hostile tumor microenvironment (TME), which features heterogeneous antigen expression, physical barriers to T-cell infiltration, and an immunosuppressive nature…
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Post-cytotoxic myeloid neoplasms: a MENA region study of clinicopathologic, genetic profile, latency determinants and prognostic predictors
Post-cytotoxic myeloid neoplasms (MN-PCT), also known as therapy-related myeloid neoplasms (t-MN), represent a heterogeneous group of hematologic malignancies that develop after a patient receives cytotoxic chemotherapy or radiotherapy for an unrelated condition. These disorders, which include therapy-related myelodysplastic syndrome (t-MDS), acute myeloid leukemia (t-AML), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN) are notorious for their aggressive nature, universally poor survival, and a lack…
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Findings from the Saudi National Breast Cancer Screening Program
Breast cancer represents the most prevalent cancer among women in the Kingdom of Saudi Arabia (KSA). To enhance early detection efforts, a detailed analysis was conducted on the data collected from the Saudi National Breast Cancer Early Detection Program The research focused on characterizing the participants and identifying predictors of positive mammography findings. A total of 8,348 Saudi women aged…
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Colorectal Cancer Screening Barriers in the UAE: A Call for Enhanced Public and Physician Education
Colorectal cancer (CRC) is a global health challenge and a major health burden within the United Arab Emirates (UAE). Despite the launch of a national CRC screening program in Abu Dhabi in 2014, a mixed-methods study aimed to understand the persistent issue of low participation and adherence among the adult population in Al-Ain has uncovered major screening barriers. The research,…
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Molecular Profiling and Targeted Therapy for Non-Small Cell Lung Cancer in the MENA Region
The treatment paradigm for advanced non-small cell lung cancer (NSCLC) has been fundamentally changed by the introduction of targeted therapies and immunotherapy over the past decade. Given that lung cancer remains a leading cause of global cancer mortality, understanding the regional molecular epidemiology is vital. This systematic review and expert opinion study aimed to determine the prevalence of key oncogenic…
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Clarithromycin-loaded Nanoparticles Enhance Antibacterial and Anticancer Performance
Researchers have successfully developed clarithromycin-loaded albumin-based nanoparticles (CLA-BSA NPs) that promise to revolutionize the delivery of antibacterial and anticancer drugs. This innovative drug delivery system, detailed in a study published in Pharmaceutics on May 31, 2025, showcases enhanced therapeutic efficacy for clarithromycin, a widely used antibiotic already known for its diverse medical applications. Clarithromycin (CLA) is a broad-spectrum antibiotic commonly…
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